About

Hoshino Lab.について
Dr. Ayuko Hoshino is an Associate Professor at Tokyo Institute of Technology. She obtained her Masters and PhD degrees at The University of Tokyo, where she studied cancer stromal fibroblasts and the tumor microenvironment and received the Excellent Thesis award. In September 2010, Dr. Hoshino joined Dr. David Lyden’s laboratory at the Weill Cornell Medicine as a visiting graduate student and learned the importance of cancer-derived exosomes in inter-cellular communication and establishment of the “soil” for cancer metastasis. Upon joining Dr. Lyden’s laboratory, she became involved in the project investigating the role of cancer-derived exosomes in metastasis and their utility as a biomarker. She led the project investigating exosomes in driving organotropism of cancer metastasis, “why cancer metastasizes to certain organs”, which remained a mystery for over a century (Hoshino et al., Nature 2015; Rodrigues*, Hoshino* et al., Nat Cell Bio. 2019). Most recently her group investigated the proteomic profile of exosomes in 426 human samples, and identified that panel of exosomal proteins could serve as a biomarker for determining cancer vs. non-cancer as well as classifying the primary tumor of origin (Hoshino et al., Cell 2020). Her laboratory’s current interest expands to exosome biology not only in cancer, but also in neurodevelopmental disease and pregnancy.

Member

メンバー紹介
PI
Ayuko Hoshino
2011 PhD (Life Science) from the University of Tokyo Current position: 2020-current Associate Professor. Department of Life Science and Technology, Tokyo Institute of Technology 2019-current Adjunct Assistant Professor, Department of Pediatrics, Weill Cornell Medicine 2019-current PRESTO researcher
Postdoctoral Researcher
NASIRI KENARI AMIRMOHAMMAD
I’m Amir, a research staff in the Hoshino laboratory interested in translational research to improve human health. I have taken my PhD under the supervision of Prof. Andrew Hill at La Trobe University in Australia. The research focus of my PhD was on pairing miRNA with Extracellular vesicles mimetic-nanovesicle to develop a novel therapeutic for Alzheimer’s disease. In 2021 I joined the laboratory of Assoc Prof. Ayuko Hoshino at the Tokyo Institute of Technology in Japan. I am working toward understanding how Extracellular vesicles mediate feto-maternal communications and how this could affect embryonic brain development, and if disruption of this inter-organ communication could be the onset of some pathophysiological conditions such as Autism. I have been actively involved in the scientific community, and I am the president of the student network on extracellular vesicles (SNEV). Outside of the pipette world, I enjoy spending time with people and learning about a new culture. I like walking through backstreets, photography with my new toy FujiFilm-X100V “Tokyo”, travelling, fusion cooking inspired by my adventures and enjoying music from all around the world. To connect with me, you can find me on Twitter at @NKAmirmohammad or email me at nasiri.a.aa@m.titech.ac.jp
The University of Tokyo Department of Reproductive, Developmental and Aging Medicine, Graduate School of Medicine 3rd-year doctoral student (D3)
Ayako Hashimoto
The University of Tokyo Department of Pharmaceutical Sciences Second-year of Graduate School (M2)
Kei Sugiura
Tokyo Institute of Technology, Department of Life Science and Technology First-year of Graduate School (M1)
Mika Sato
Tokyo Institute of Technology, Department of Life Science and Technology 4th year of undergraduate (Junior)
Hinako Shimura
Tokyo Institute of Technology, Department of Life Science and Technology 4th year of undergraduate (Junior)
Yuto Hamazaki
Tokyo Institute of Technology, Department of Life Science and Technology 3rd year of undergraduate (Junior)
Tamaha Ogawa
Tokyo Institute of Technology, Department of Life Science and Technology 3rd year of undergraduate (Junior)
Mantaro Kawaguchi
Technical Researcher
Naoko Takahashi 
Secretary / Technical Researcher
Yuma Wakusaka

Access

アクセス
Hoshino Laboratory
B1/B2 Building-Room629
4259 Nagatsuta-cho, Midori-ku,
Yokohama, Kanagawa 226-8501
Mailbox B-45
TEL/FAX +81-45-924-5139