About

Hoshino Lab.について
Dr. Ayuko Hoshino is an Associate Professor at Tokyo Institute of Technology. She obtained her Masters and PhD degrees at The University of Tokyo, where she studied cancer stromal fibroblasts and the tumor microenvironment and received the Excellent Thesis award. In September 2010, Dr. Hoshino joined Dr. David Lyden’s laboratory at the Weill Cornell Medicine as a visiting graduate student and learned the importance of cancer-derived exosomes in inter-cellular communication and establishment of the “soil” for cancer metastasis. Upon joining Dr. Lyden’s laboratory, she became involved in the project investigating the role of cancer-derived exosomes in metastasis and their utility as a biomarker. She led the project investigating exosomes in driving organotropism of cancer metastasis, “why cancer metastasizes to certain organs”, which remained a mystery for over a century (Hoshino et al., Nature 2015; Rodrigues*, Hoshino* et al., Nat Cell Bio. 2019). Most recently her group investigated the proteomic profile of exosomes in 426 human samples, and identified that panel of exosomal proteins could serve as a biomarker for determining cancer vs. non-cancer as well as classifying the primary tumor of origin (Hoshino et al., Cell 2020). Her laboratory’s current interest expands to exosome biology not only in cancer, but also in neurodevelopmental disease and pregnancy.

Member

メンバー紹介
PI
Ayuko Hoshino
2011 PhD (Life Science) from the University of Tokyo Current position: 2023-current Professor. Research Center for Advanced Science and Technology, the University of Tokyo 2020-2023 Associate Professor. Department of Life Science and Technology, Tokyo Institute of Technology 2019-current Adjunct Assistant Professor, Department of Pediatrics, Weill Cornell Medicine 2019-current PRESTO researcher
Assistant Professor
Naotaka Izuo
2013 PhD (Pharmaceutical Sciences) from Kyoto University. Keywords: Neuroscience, Gerontology, Exosome, Alzheimer's disease, Psychiatric diseases, Brain-peripheral communication. Love music, sports & science.
Postdoctoral Researcher
NASIRI KENARI AMIRMOHAMMAD
I’m Amir, a research staff in the Hoshino laboratory interested in translational research to improve human health. I have taken my PhD under the supervision of Prof. Andrew Hill at La Trobe University in Australia. The research focus of my PhD was on pairing miRNA with Extracellular vesicles mimetic-nanovesicle to develop a novel therapeutic for Alzheimer’s disease. In 2021 I joined the laboratory of Assoc Prof. Ayuko Hoshino at the Tokyo Institute of Technology in Japan. I am working toward understanding how Extracellular vesicles mediate feto-maternal communications and how this could affect embryonic brain development, and if disruption of this inter-organ communication could be the onset of some pathophysiological conditions such as Autism. I have been actively involved in the scientific community, and I am the president of the student network on extracellular vesicles (SNEV). Outside of the pipette world, I enjoy spending time with people and learning about a new culture. I like walking through backstreets, photography with my new toy FujiFilm-X100V “Tokyo”, travelling, fusion cooking inspired by my adventures and enjoying music from all around the world. To connect with me, you can find me on Twitter at @NKAmirmohammad or email me at nasiri.a.aa@m.titech.ac.jp
Researcher
Yuichi Shoburu
Researcher
Mami Kato
Researcher
Michihiro Maemoto
Researcher
Ayami Gouda
Researcher
Taiki Kayukawa
The University of Tokyo, Department of Advanced Interdisciplinary Studies, Graduate School of Engineering (D2)
Kei Sugiura
The University of Tokyo, Department of Advanced Interdisciplinary Studies, Graduate School of Engineering (D1)
Yuto Hamazaki
The University of Tokyo, Department of Advanced Interdisciplinary Studies, Graduate School of Engineering (D1)
Mai Honjo
Tokyo Institute of Technology, Department of Life Science and Technology (M2)
Tamaha Ogawa
Tokyo Institute of Technology, Department of Life Science and Technology (M2)
Mantaro Kawaguchi
Exchange Researcher
Masafumi Maruo
I joined Hoshino Lab as a researcher in April 2024. I have been engaged in clinical practice as an urologist, and I aim to clarify unknown areas of urological diseases through exosome research. I love beer and plan to visit brewery pubs in Tokyo, too.
Technical Assistant Staff
Sedgh Zahra
I work as a technical assistant in the Hoshino laboratory. I have a passion for photography and love going for a jog during the sunrise. Additionally, I am a big fan of Japanese cuisine and sweets. On weekends, I like to visit new shrines and collect Goshuin.
Secretary / Administrative Assistant Staff
Yuma Wakusaka
Alumni & Alumnae

Access

アクセス
Hoshino Laboratory
Hoshino LaResearch Center for Advanced Science and Technology, the University of Tokyo
Intercellular Communication & Medical Scienceboratory
Building No.3-Room612, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904 JAPAN
Tel+81-3-5452-5207 ex:55207