About

Hoshino Lab.について
Hoshino Lab. was established by PI (Professor) Ayuko Hoshino in March 2020. Prof. Hoshino studied "cancer stromal fibroblasts" and "cancer microenvironment" while at the University of Tokyo. As an international student, she joined the laboratory of Dr. David Lyden at Weill Cornell Medicine University School of Medicine, where she learned the importance of cancer-derived exosomes in the formation of "soil" for intercellular communication and cancer metastasis. While there, he led a project to define the characteristics of exosomes that drive the organ specificity of cancer metastasis, a question that has remained a mystery for over 100 years: why do cancers metastasize to specific organs? He also investigated the proteomic profiles of exosomes in 426 human samples and demonstrated that a panel of exosomal proteins could serve as biomarkers not only to determine cancer versus noncancer, but also to classify primary sites. Currently, we are not only developing these studies, but are also working on exosome biology in neurological diseases and pregnancy. ​

Member

メンバー紹介
PI
Ayuko Hoshino
2011 PhD (Life Science) from the University of Tokyo Current position: 2023-current Professor. Research Center for Advanced Science and Technology, the University of Tokyo 2020-2023 Associate Professor. Department of Life Science and Technology, Tokyo Institute of Technology 2019-current Adjunct Assistant Professor, Department of Pediatrics, Weill Cornell Medicine 2019-current PRESTO researcher
Assistant Professor
Naotaka Izuo
2013 PhD (Pharmaceutical Sciences) from Kyoto University. Keywords: Neuroscience, Gerontology, Exosome, Alzheimer's disease, Psychiatric diseases, Brain-peripheral communication. Love music, sports & science.
Postdoctoral Researcher
NASIRI KENARI AMIRMOHAMMAD
I’m Amir, a research staff in the Hoshino laboratory interested in translational research to improve human health. I have taken my PhD under the supervision of Prof. Andrew Hill at La Trobe University in Australia. The research focus of my PhD was on pairing miRNA with Extracellular vesicles mimetic-nanovesicle to develop a novel therapeutic for Alzheimer’s disease. In 2021 I joined the laboratory of Assoc Prof. Ayuko Hoshino at the Tokyo Institute of Technology in Japan. I am working toward understanding how Extracellular vesicles mediate feto-maternal communications and how this could affect embryonic brain development, and if disruption of this inter-organ communication could be the onset of some pathophysiological conditions such as Autism. I have been actively involved in the scientific community, and I am the president of the student network on extracellular vesicles (SNEV). Outside of the pipette world, I enjoy spending time with people and learning about a new culture. I like walking through backstreets, photography with my new toy FujiFilm-X100V “Tokyo”, travelling, fusion cooking inspired by my adventures and enjoying music from all around the world. To connect with me, you can find me on Twitter at @NKAmirmohammad or email me at nasiri.a.aa@m.titech.ac.jp
Researcher
Yuichi Shoburu
Researcher
Mami Kato
Researcher
Michihiro Maemoto
Researcher
Ayami Gouda
Researcher
Taiki Kayukawa
Exchange Researcher
Masafumi Maruo
I joined Hoshino Lab as a researcher in April 2024. I have been engaged in clinical practice as an urologist, and I aim to clarify unknown areas of urological diseases through exosome research. I love beer and plan to visit brewery pubs in Tokyo, too.
The University of Tokyo, Department of Advanced Interdisciplinary Studies, Graduate School of Engineering (D2)
Kei Sugiura
The University of Tokyo, Department of Advanced Interdisciplinary Studies, Graduate School of Engineering (D1)
Yuto Hamazaki
The University of Tokyo, Department of Advanced Interdisciplinary Studies, Graduate School of Engineering (D1)
Mai Honjo
Tokyo Institute of Technology, Department of Life Science and Technology (M2)
Tamaha Ogawa
Tokyo Institute of Technology, Department of Life Science and Technology (M2)
Mantaro Kawaguchi
The University of Tokyo, Faculty of Education and Culture, Department of Science, Exchange Trainee
Aiki Nakanishi
Technical Assistant Staff
Sedgh Zahra
I work as a technical assistant in the Hoshino laboratory. I have a passion for photography and love going for a jog during the sunrise. Additionally, I am a big fan of Japanese cuisine and sweets. On weekends, I like to visit new shrines and collect Goshuin.
Secretary / Administrative Assistant Staff
Yuma Wakusaka
Alumni & Alumnae

Access

アクセス
Hoshino Laboratory
Research Center for Advanced Science and Technology,
the University of Tokyo Intercellular Communication & Medical Science Hoshino Laboratory

Building No.3-Room612, Komaba Ⅱ Campus 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904 JAPAN
Tel+81-3-5452-5207 ex:55207