About

Hoshino Lab. was established by Prof. Ayuko Hoshino in March 2020. She obtained her Masters and PhD degrees at The University of Tokyo, where she studied cancer stromal fibroblasts and the tumor microenvironment and received the Excellent Thesis award. In September 2010, she joined Dr. David Lyden’s laboratory at the Weill Cornell Medicine as a visiting graduate student and learned the importance of cancer-derived exosomes in inter-cellular communication and establishment of the “soil” for cancer metastasis. Upon joining Dr. Lyden’s laboratory, she became involved in the project investigating the role of cancer-derived exosomes in metastasis and their utility as a biomarker. She led the project investigating exosomes in driving organotropism of cancer metastasis, “why cancer metastasizes to certain organs”, which remained a mystery for over a century (Hoshino et al., Nature 2015; Rodrigues*, Hoshino* et al., Nat Cell Bio. 2019). Most recently her group investigated the proteomic profile of exosomes in 426 human samples, and identified that panel of exosomal proteins could serve as a biomarker for determining cancer vs non-cancer as well as classifying the primary tumor of origin (Hoshino et al., Cell 2020). Her laboratory’s current interest expands to exosome biology not only in cancer, but also in neurodevelopmental disease and pregnancy. ​